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How Much Benadryl to Give a 70 lb Dog? The general recommended dosage of Benadryl for dogs is 1 mg per pound of body weight, given 2-3 times a day. Therefore, for a 70 lb dog, the typical dosage would be around 70 mg, split into 2-3 doses throughout the day. melodetta info Antihistamines: My favorite antihistamines I use in dogs are Zyrtec and Benadryl. Usually, I will start with 5mg Zyrtec in a small dog (under 20 Administer 1 milligram per pound of body weight. This is the general rule of thumb when giving Benadryl to a dog. Since dogs can be many different weights, you